Contribuie la prevenirea apariției afecțiunilor degenerative (Parkinson, Alzheimer, scleroză multiplă, sindrom metabolic – diabet etc.)
INGREDIENTE:
Vitamina C Alcalină – (L- ascorbat de sodiu)
Soc – flori (Sambucus nigra)
Turmeric – rădăcină (Curcuma longa)
Astragalus – rădăcină (Astragalus membranaceus)
Ceai verde – frunze (Camellia sinensis), extract apos 4:1 cu 40% polifenoli
EFECTE:
- Contribuie la reducerea proceselor inflamatorii de la nivelul articulațiior (artrită, artrită reumatoida);
- Contribuie la apoptoza și inhibarea dezvoltării celulelor tumorale, reducerea cancerului;
- Contribuie la reducerea efectelor secundare în cazul chimioterapiei, radioterapiei;
- Susține funcționarea normală a sistemului imunitar, îmbunatatirea funcționarii rinichilor și a sistemului cardiovascular;
- Contribuie la protejarea ADN-ului față de agresiunea factorilor perturbatori;
- Contribuie la menținerea în bune condiții a pereților vaselor de sânge a elasticității venelor și arterelor, reducerea plăcilor de aterom
- Contribuie la favorizarea absorbției substanțelor nutritive și la stimularea proceselor de regenerare a țesuturilor;
- Contribuie la procesele de reglare a metabolismului glucidic și lipidic și la scaderea nivelului de colesterol LDL din sânge;
- Contribuie la îmbunătățirea funcționarii sistemului digestiv, a ficatului și vezicii biliare;
Vitamina C (L–ascorbat de sodiu)
- Sodium ascorbate (SA) and l-ascorbic acid (AA) as modifiers of burn affected skin – A comparative analysis. Spectrochim Acta A Mol Biomol Spectrosc. 2019 Feb 15;209:55-61. doi: 10.1016/j.saa.2018.10.021. Epub 2018 Oct 16. Pielesz A, Ślusarczyk C, Biniaś D, Bobiński R.
- Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82. doi: 10.1016/j.jdermsci.2014.05.011. Epub 2014 Jun 11. Hinek A, Kim HJ, Wang Y, Wang A, Mitts TF.
- Evaluation of Uracil, Sodium Ascorbate, and Rosiglitazone as Promoters of Urinary Bladder Transitional Cell Carcinomas in Male Sprague-Dawley Rats. Toxicol Pathol. 2018 Feb;46(2):147-157. doi: 10.1177/0192623318756004. Tirmenstein M, Janovitz E, Dorr T, Song Y, Chen SJ, Granaldi K, Chadwick KD, Mangipudy R, Graziano M, Attalla B, Haile S, Czajkowski M, Foster JR, Bergholm AM, Billger M, Söderberg M.
- Dopamine-Induced Ascorbate Release From Retinal Neurons Involves Glutamate Release, Activation of AMPA/Kainate Receptors and Downstream Signaling Pathways Camila Cabral Portugal, Thaísa Godinho da Encarnação, Ivan Domith, Alexandre dos Santos Rodrigues, Nádia Almeida de Oliveira, Renato Socodato, and Roberto Paes-de-Carvalho PMCID: PMC6521073PMID: 31143097Front Neurosci. 2019; 13: 453.Published online 2019 May 9. doi: 10.3389/fnins.2019.00453
- Colon cleansing efficacy and safety with 1 L NER1006 versus 2 L polyethylene glycol + ascorbate: a randomized phase 3 trial. Bisschops R, Manning J, Clayton LB, Ng Kwet Shing R, Álvarez-González M; MORA Study Group. Endoscopy. 2019 Jan;51(1):60-72. doi: 10.1055/a-0638-8125. Epub 2018 Jul 19.
- Restoration of 5‐hydroxymethylcytosine by ascorbate blocks kidney tumour growth Guangzhe Ge, Ding Peng, Ziying Xu, Bao Guan, Zijuan Xin, Qun He, Yuanyuan Zhou, Xuesong Li, Liqun Zhou and Weimin Ci PMCID: PMC6073201 PMID: 29959161 EMBO Rep. 2018 Aug; 19(8): e45401.Published online 2018 Jun 28. doi: 10.15252/embr.201745401
Soc (Sambucus nigra)
- The Content of Selected Minerals, Bioactive Compounds, and the Antioxidant Properties of the Flowers and Fruit of Selected Cultivars and Wildly Growing Plants of Sambucus nigraL. Młynarczyk K, Walkowiak-Tomczak D, Staniek H, Kidoń M, Łysiak GP. Molecules. 2020 Feb 17;25(4). pii: E876. doi: 10.3390/molecules25040876.
- A Green Extraction Process for Polyphenols from Elderberry (Sambucus nigra) Flowers Using Deep Eutectic Solvent and Ultrasound-Assisted Pretreatment. Kaltsa O, Lakka A, Grigorakis S, Karageorgou I, Batra G, Bozinou E, Lalas S, Makris DP. Molecules. 2020 Feb 19;25(4). pii: E921. doi: 10.3390/molecules25040921.
- Molecular characterization of a novel Aureusvirus infecting elderberry (Sambucus nigraL.). Šafářová D, Vavroušková K, Candresse T, Navrátil M. PLoS One. 2018 Aug 16;13(8):e0200506. doi: 10.1371/journal.pone.0200506. eCollection 2018.
- Concentration of Bioactive Compounds from Elderberry (Sambucus nigraL.) Juice by Nanofiltration Membranes. Tundis R, Loizzo MR, Bonesi M, Sicari V, Ursino C, Manfredi I, Conidi C, Figoli A, Cassano A. Plant Foods Hum Nutr. 2018 Aug 8. doi: 10.1007/s11130-018-0686-x.
- Identification of Peptides in Flowers of Sambucus nigrawith Antimicrobial Activity against Aquaculture Pathogens. Álvarez CA, Barriga A, Albericio F, Romero MS, Guzmán F. Molecules. 2018 Apr 27;23(5). pii: E1033. doi: 10.3390/molecules23051033.
- Lectin binding patterns in normal, dysplastic and Helicobacter pylori infected gastric mucosa. Vernygorodskyi S, Shkolnikov V, Suhan D. Exp Oncol. 2017 Jul;39(2):138-140.
- The kinetics of thermal degradation of polyphenolic compounds from elderberry ( Sambucus nigraL.) extract. Oancea AM, Onofrei C, Turturica M, Bahrim G, Rapeanu G, Stanciuc N. Food Sci Technol Int. 2018 Jun;24(4):361-369. doi: 10.1177/1082013218756139. Epub 2018 Feb 6.
- Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review. Akram M, Tahir IM, Shah SMA, Soc (Sambucus nigra) Mahmood Z, Altaf A, Ahmad K, Munir N, Daniyal M, Nasir S, Mehboob H. Phytother Res. 2018 May;32(5):811-822. doi: 10.1002/ptr.6024. Epub 2018 Jan 22. Review.
- Polyphenolic content, antiradical activity, stability and microbiological quality of elderberry (Sambucus nigra L.) extracts. Pliszka B.Acta Sci Pol Technol Aliment. 2017 Oct-Dec;16(4):393-401. doi: 10.17306/J.AFS.0523. PMID:29241318
- Interfering With Lipid Raft Association: A Mechanism to Control Influenza Virus Infection By Sambucus Nigra. Shahsavandi S, Ebrahimi MM, Hasaninejad Farahani A. Iran J Pharm Res. 2017 Summer;16(3):1147-1154.
- Chlorogenic acid isomer contents in 100 plants commercialized in Brazil. Meinhart AD, Damin FM, Caldeirão L, da Silveira TFF, Filho JT, Godoy HT. Food Res Int. 2017 Sep;99(Pt 1):522-530. doi: 10.1016/j.foodres.2017.06.017.
- Plant-made virus-like particles bearing influenza hemagglutinin (HA) recapitulate early interactions of native influenza virions with human monocytes/macrophages. Makarkov AI, Chierzi S, Pillet S, Murai KK, Landry N, Ward BJ. Vaccine. 2017 Aug 16;35(35 Pt B):4629-4636. doi: 10.1016/j.vaccine.2017.07.012.
- Sorafenib induced alteration of protein glycosylation in hepatocellular carcinoma cells. Liu T, Liu R, Zhang S, Guo K, Zhang Q, Li W, Liu Y. Oncol Lett. 2017 Jul;14(1):517-524. doi: 10.3892/ol.2017.6177.
- Sorafenib induced alteration of protein glycosylation in hepatocellular carcinoma cells. Liu T, Liu R, Zhang S, Guo K, Zhang Q, Li W, Liu Y. Oncol Lett. 2017 Jul;14(1):517-524. doi: 10.3892/ol.2017.6177.
- Label-free chronopotentiometric glycoprofiling of prostate specific antigen using sialic acid recognizing lectins. Belicky S, Černocká H, Bertok T, Holazova A, Réblová K, Paleček E, Tkac J, Ostatná V. Bioelectrochemistry. 2017 Oct;117:89-94. doi: 10.1016/j.bioelechem.2017.06.005. Epub 2017 Jun 19.
- Lectin array and glycogene expression analyses of ovarian cancer cell line A2780 and its cisplatin-resistant derivate cell line A2780-cp. Zhao R, Qin W, Qin R, Han J, Li C, Wang Y, Xu C. Clin Proteomics. 2017 May 23;14:20. doi: 10.1186/s12014-017-9155-z. eCollection 2017.
- Polyphenols Pattern and Correlation With Antioxidant Activities of Berries Extracts From Four Different Populations of Sicilian Sambucus Nigra L Manuela Mandrone, Beatrice Lorenzi, Antonella Maggio, Tommaso La Mantia, Monica Scordino, Maurizio Bruno, Ferruccio Poli Nat Prod Res. 2014;28(16):1246-53. doi: 10.1080/14786419.2014.898147. Epub 2014 Mar
Turmeric (Curcuma longa)
- Usha T, Pradhan S, Goyal AK, Dhivya S, Kumar HPP, Singh MK, Joshi N, Basistha BC, Murthy KRS, Selvaraj S, Middha SK. Molecular Simulation-based Combinatorial Modeling and Antioxidant Activities of Zingiberaceae Family Rhizomes.Pharmacogn Mag. 2017 Oct;13(Suppl 3):S715-S722. doi: 10.4103/pm.pm_82_17. Epub 2017 Oct 11. PMID:29142438 Free PMC Article https://www.ncbi.nlm.nih.gov/pubmed/29142438
- Naqvi A, Malasoni R, Gupta S, Srivastava A, Pandey RR, Dwivedi AK. <i>In Silico</i> and <i>In Vitro</i> Anticancer Activity of Isolated Novel Marker Compound from Chemically Modified Bioactive Fraction from <i>Curcuma longa</i> (NCCL). Pharmacogn Mag. 2017 Oct;13(Suppl 3):S640-S644. doi: 10.4103/pm.pm_23_17. Epub 2017 Jul 18. PMID:29142426 Free PMC Article https://www.ncbi.nlm.nih.gov/pubmed/29142426
- Mou S, Zhou Z, He Y, Liu F, Gong L. Curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer cells through Bcl-2 and PI3K/Akt, and by upregulating miR-15a. Oncol Lett. 2017 Oct;14(4):4937-4942. doi: 10.3892/ol.2017.6739. Epub 2017 Aug 10. PMID: 29085504 Free PMC Article https://www.ncbi.nlm.nih.gov/pubmed/29085504
- Curcumin inhibits the proliferation and induces apoptosis in HT-29 cell lines through a reactive oxygen species (ROS)-dependent mechanism. Wang J, Qi L, Mei L, Wu Z.Pak J Pharm Sci. 2017 Sep;30 (5):1671-1677. PMID:29084689
- Curcumin Activates AMPK Pathway and Regulates Lipid Metabolism in Rats Following Prolonged Clozapine Exposure.Liu Z, Cui C, Xu P, Dang R, Cai H, Liao D, Yang M, Feng Q, Yan X, Jiang P. Front Neurosci. 2017 Oct 4;11:558. doi: 10.3389/fnins.2017.00558. eCollection 2017. PMID:29046626 Free PMC Article https://www.ncbi.nlm.nih.gov/pubmed/29046626
- Curcumol inhibits the proliferation of gastric adenocarcinoma MGC-803 cells via downregulation of IDH1. Zang S, Tang Q, Dong F, Liu H, Li L, Guo F, Pan X, Lin H, Zeng W, Cai Z, Zhong Q, Zang N, Zang L. Oncol Rep. 2017 Dec;38(6):3583-3591. doi: 10.3892/or.2017.6028. Epub 2017 Oct 12. PMID: 29039582 https://www.ncbi.nlm.nih.gov/pubmed/29039582
- http://ayurvedic-medica.ro/site/produsele-noastre/sanohelp/64-proprietatile-turmericului-fac-radioterapia-si-chimioterapia
- Curcuma longa Extract Exerts a Myorelaxant Effect on the Ileum and Colon in a Mouse Experimental Colitis Model, Independent of the Anti-Inflammatory Effect, Rita Aldini, Roberta Budriesi, Giulia Roda, Matteo Micucci, Pierfranco Ioan, Antonia D’Errico-Grigioni, Alessandro Sartini, Elena Guidetti, Margherita Marocchi, Monica Cevenini, Francesca Rosini, Marco Montagnani, Alberto Chiarini, Giuseppe Mazzella PLoS One. 2012; 7(9): e44650. Published online 2012 Sep 12. doi: 10.1371/journal.pone.0044650, PMCID: PMC3440350
- Hepatic protection and anticancer activity of curcuma: A potential chemopreventive strategy against hepatocellular carcinoma, YAN LI, XUE SHI, JINGWEN ZHANG, XIANG ZHANG, ROBERT C.G. MARTIN, Int J Oncol. 2014 Feb; 44(2): 505–513. Published online 2013 Nov 21. doi: 10.3892/ijo.2013.2184, PMCID: PMC3898719 • De Novo Transcriptome Assembly (NGS) of Curcuma longa L. Rhizome Reveals Novel Transcripts Related to Anticancer and Antimalarial Terpenoids, Ramasamy S. Annadurai, Ramprasad Neethiraj, Vasanthan Jayakumar, Anand C. Damodaran, Sudha Narayana Rao, Mohan A. V. S. K. Katta, Sreeja Gopinathan, Santosh Prasad Sarma, Vanitha Senthilkumar, Vidya Niranjan, Ashok Gopinath, Raja C. Mugasimangalam, PLoS One. 2013; 8(2): e56217. Published online 2013 Feb 28. doi: 10.1371/journal.pone.0056217, PMCID: PMC3585318 • Inhibition of lung cancer cells A549 and H460 by curcuminoid extracts and nanoemulsions prepared from Curcuma longa Linnaeus, Hong-Bin Chang, Bing-Huei Chen, Int J Nanomedicine. 2015; 10: 5059–5080. Published online 2015 Aug 5. doi: 10.2147/IJN.S87225, PMCID: PMC4531038 • Combinatorial cytotoxic effects of Curcuma longa and Zingiber officinaleon the PC-3M prostate cancer cell line, Kesava Rao V. Kurapati, Thangavel Samikkannu, Dakshayani B. Kadiyala, Saiyed M. Zainulabedin, Nimisha Gandhi, Sadhana S. Sathaye, Manohar A. Indap, Nawal Boukli, Jose W. Rodriguez, Madhavan P.N. Nair, J Basic Clin Physiol Pharmacol. Author manuscript; available in PMC 2015 Sep 7., Published in final edited form as: J Basic Clin Physiol Pharmacol. 2012; 23(4): 139–146.doi: 10.1515/jbcpp-2012-0021, PMCID: PMC4561547 • Effect of Curcuma longa and Ocimum sanctum on myocardial apoptosis in experimentally induced myocardial ischemic-reperfusion injury, Ipseeta Mohanty, Dharamvir Singh Arya, Suresh Kumar Gupta, BMC Complement Altern Med. 2006; 6: 3. Published online 2006 Feb 19. doi: 10.1186/1472-6882-6-3, PMCID: PMC1397864 • Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa, Grace G. L. Yue, Ben C. L. Chan, Po-Ming Hon, Mavis Y. H. Lee, Kwok-Pui Fung, Ping-Chung Leung, Clara B. S. Lau, Food Chem Toxicol. Author manuscript; available in PMC 2011 Aug 1., Published in final edited form as: Food Chem Toxicol. 2010 Aug–Sep; 48(8-9): 2011–2020. Published online 2010 May, 9. doi: 10.1016/j.fct.2010.04.039, PMCID: PMC2910176 • Hepatoprotective and immunomodulatory properties of aqueous extract of Curcuma longa in carbon tetra chloride intoxicated Swiss albino mice, Mahuya Sengupta, Gauri Dutta Sharma, Biswajit Chakraborty, Asian Pac J Trop Biomed. 2011 Jun; 1(3): 193–199. doi: 10.1016/S2221-1691(11)60026-9, PMCID: PMC3609192 • A Standardized Chemically Modified Curcuma longa Extract Modulates IRAK-MAPK Signaling in Inflammation and Potentiates Cytotoxicity, Minakshi Rana, Preeti Maurya, Sukka S. Reddy, Vishal Singh, Hafsa Ahmad, Anil K. Dwivedi, Madhu Dikshit, Manoj K. Barthwal, Front Pharmacol. 2016; 7: 223. Published online 2016 Jul 25. doi: 10.3389/fphar.2016.00223, PMCID: PMC4959270
- Immunostimulatory activities of polysaccharide extract isolated from Curcuma longa, Grace G. L. Yue, Ben C. L. Chan, Po-Ming Hon, Kwok-Pui Fung, Ping-Chung Leung, Clara B. S. Lau, Int J Biol Macromol. Author manuscript; available in PMC 2011 Oct 1., Published in final edited form as: Int J Biol Macromol. 2010 Oct 1; 47(3): 342–347. Published online 2010 Jun 1.doi: 10.1016/j.ijbiomac.2010.05.019, PMCID: PMC2917522
- Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity, Ana Claudia F. Amaral, Luciana A. Gomes, Jefferson Rocha de A. Silva, José Luiz P. Ferreira, Aline de S. Ramos, Maria do Socorro S. Rosa, Alane B. Vermelho, Igor A. Rodrigues, Biomed Res Int. 2014; 2014: 694934. Published online 2014 J, 18. doi: 10.1155/2014/694934, PMCID: PMC4087288
- Evaluation of phenolic profile, antioxidant and anticancer potential of two main representants of Zingiberaceae family against B164A5 murine melanoma cells, Corina Danciu, Lavinia Vlaia, Florinela Fetea, Monica Hancianu, Dorina E Coricovac, Sorina A Ciurlea, Codruta M Soica, Iosif Marincu, Vicentiu Vlaia, Cristina A Dehelean, Cristina Trandafirescu, Biol Res. 2015; 48(1): 1. Published online 2015 Jan 12. doi: 10.1186/0717-6287-48-1, PMCID:PMC44172
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- ,,Pharmacogenomic Characterization and Isobologram Analysis of the Combination of Ascorbic Acid and Curcumin-Two Main Metabolites of Curcuma longa-in Cancer Cells.” Ooko E, Kadioglu O, Greten HJ, Efferth T. Front Pharmacol. 2017 Feb 2;8:38. doi: 10.3389/fphar.2017.00038. PMID: 28210221 https://www.ncbi.nlm.nih.gov/pubmed/28210221
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Astragalus (Astragalus membranaceus)
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- „Green Tea Catechins and Their Oxidative Protection in the Rat Eye.”. Vol. 58, No. 3. Journal of Agricultural and Food Chemistry. February 2010. pp. 1523–1534. text. Retrieved 2010-02-19.
- About.com. The History of Tea – Tea Bags and Makers
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- BBC news – 17 March 2009 – green tea may have the power to ward off breast cancer
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Polyphenols: Potential Future Arsenals in the Treatment of Diabetes. Solayman M, Ali Y, Alam F, Islam MA, Alam N, Khalil MI, Gan SH. Curr Pharm Des. 2016;22(5):549-65. Review. PMID:26601968 https://www.ncbi.nlm.nih.gov/pubmed/26601968Natural Products for the Treatment of Type 2 Diabetes Mellitus. Ríos JL, Francini F, Schinella GR. Planta Med. 2015 Aug;81(12-13):975-94. doi: 10.1055/s-0035-1546131. Epub 2015 Jul 1. Review. PMID:26132858 https://www.ncbi.nlm.nih.gov/pubmed/26132858GreenHYPERLINK „https://www.ncbi.nlm.nih.gov/pubmed/28664072” tea and type 2 diabetes. Park JH, Bae JH, Im SS, Song DK. Integr Med Res. 2014 Mar;3(1):4-10. doi: 10.1016/j.imr.2013.12.002. Epub 2013 Dec 14. Review. PMID:28664072 Free PMC Article https://www.ncbi.nlm.nih.gov/pubmed/28664072CoffeeHYPERLINK „https://www.ncbi.nlm.nih.gov/pubmed/24071782” and tea: perks for health and longevity? Bhatti SK, O’Keefe JH, Lavie CJ. Curr Opin Clin Nutr Metab Care. 2013 Nov;16(6):688-97. doi: 10.1097/MCO.0b013e328365b9a0. Review.
PMID: 24071782 https://www.ncbi.nlm.nih.gov/pubmed/24071782
CoffeeHYPERLINK „https://www.ncbi.nlm.nih.gov/pubmed/21631956” and tea consumption in relation to inflammation and basal HYPERLINK
„https://www.ncbi.nlm.nih.gov/pubmed/21631956″glucoseHYPERLINK „https://www.ncbi.nlm.nih.gov/pubmed/21631956” metabolism in a multi-ethnic Asian population: a cross-sectional study. Rebello SA, Chen CH, Naidoo N, Xu W, Lee J, Chia KS, Tai ES, van Dam RM. Nutr J. 2011 Jun 2;10:61. doi: 10.1186/1475-2891-10-61.
PMID: 21631956 Free PMC Article https://www.ncbi.nlm.nih.gov/pubmed/21631956
Green Tea Blocks HIV in Test Tubes
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Lambert JD, Sang S, Yang CS (April 2007). „Possible controversy over dietary polyphenols: benefits vs risks”.Chem. Res. Toxicol. 20 (4): 583–5. text.
Strick et al.; Strissel, PL; Borgers, S; Smith, SL; Rowley, JD (2000). „Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia.”. Proc. Natl. Acad. Sci. USA 97 (9): 4790–4795. abstract.
Kaijun Niu et al (2009). „Green tea consumption is associated with depressive symptoms in the elderly”. Am J Clin Nutr. 90 (6): 1615–22. text.
Golden, E.; Lam, PY; Kardosh, A; Gaffney, KJ; Cadenas, E; Louie, SG; Petasis, NA; Chen, TC et al. (2009). „Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors.”.Blood 113 (23): 5927–5937.
Neith, Katie. „Green tea blocks benefits of cancer drug, study finds”. text.
Sarma DN, Barrett ML, Chavez ML, et al. (2008). „Safety of green tea extracts : a systematic review by the US Pharmacopeia”. Drug Saf 31 (6): 469–84. text.
Master Lam Kam Cheun et al. (2002). The way of tea. Gaia Books. ISBN 1856751430.
John C, Evans, Tea in China: The History of China’s National Drink. Greenwood Press, 1992.
Green Tea (an overview from the University of Maryland Medical Center)
Green Tea and Body Shape (overview from the Lipton Institute of Tea)
Green Tea’s cancer fighting potential (Audio interview).
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